PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12294/2425

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Evaluating the Brainstem in Children With Breathholding Spells
(Kare Publishing, 2022) Ozcora, Gul Demet Kaya; Kumandas, Sefer; Sagiroglu, Ayse; Acer, Niyazi; Doganay, Selim; Yigit, Huseyin; Gumus, Hakan
OBJECTIVE: Breath-holding spells (BHSs) are a non-epileptic paroxysmal phenomenon characterized by frequent apnea episodes, loss of consciousness, and changes in skin tone and postural tone triggered by negative stimuli of childhood. The pathophysiology of the disease remains unclear; autonomic dysregulation caused by delayed myelination is believed to play a role. In this study, we aimed to evaluate the brainstems of children with BHS using diffusion tensor imaging (DTI) and investigate the etiology of this phenomenon. METHODS: The study group consisted of 16 children with a history of severe breath-holding episodes (accompanied by loss of consciousness and tonic contraction due to prolonged anoxic response) and 18 age-, gender-, and handedness-matched controls. All children underwent systemic, neurologic, and cardiologic evaluation, including complete blood count, blood bio-chemistry, serum iron and ferritin level, serum vitamin B12 level, electrocardiogram, and electroencephalograms. Magnetic resonance imaging was performed using a 1.5-Tesla Siemens Aera scanner (Siemens, Germany). RESULTS: Evaluation of brainstem (midbrain, pons, and medulla oblongata) volumes revealed no statistically significant differences between the BHS patient and control groups. In a voxel-wise analysis of DTI data, the BHS patient group had significantly lower fractional anisotropy (FA) values than the control group in the bilateral midbrain and medulla, right cortico-spinal tract, bilateral corpus callosum body and splenium, and left corpus callosum genu. In contrast, there were no significant differences in FA values in the pons, cerebellum, left corticospinal tract, and right corpus callosum genu. CONCLUSION: Based on our findings, we think that patients with BHS should be treated with an approach similar to other neurodevelopmental diseases and that this study may help elucidate the pathophysiology and establish the groundwork for future studies on its treatment.
Citation - WoS: 1
Citation - Scopus: 1
Morphometric Evaluation of the Human Hippocampus and Hippocampal Subfield Volume Characteristics by VolBrain/HIPS
(Springer, 2026) Ozen, Kemal Emre; Saglam, Ozge Coskun; Karagoz, Cansu Kibar; Yenigul, Hatice; Bagheri, Hassan; Sahin, Turgay; Acer, Niyazi
In the literature, research often utilizes digital segmentation methods like VolBrain, aiding in anatomical understanding. However, racial and population-specific differences remain unclear but may be important for clinical interpretation. We seek to enhance clinical perspectives by providing normative data and insights into hippocampal morphology, potentially advancing diagnostic and prognostic methodologies in neurological disorders. We think that it is necessary to discuss the reported asymmetry data by VolBrain. There might be inaccuracies or inconsistencies in how asymmetry is measured and reported. MRIs of the 138 healthy individuals (66 females, 72 males) were included. The VolBrain-HIPS pipeline was preferred for automatic segmentation. Alternative methods were recruited, including the total hippocampal volume for the adjustment of the volumetric data. Asymmetry index was accepted as the indicator of the magnitude of the asymmetry and negative asymmetry index data was positivized. Gender and side comparisons of the hippocampal data were presented not only for absolute measurement but also for the adjusted volumetric data. Comparisons for the magnitude of the asymmetry were carried out as well as the regression modeling based on age and gender. Hippocampus-adjusted volume information should also be considered when analyzing VolBrain data and making clinical or anatomical decisions. The asymmetry data produced by VolBrain should be considered as a magnitude scale of the asymmetry in individuals with right or left dominant hippocampus or hippocampus subfield. Alternative significant regression models were introduced to observe how the volumetric numerical composition of the hippocampus subfields changes with age.
The Role of Lateralisation and Sex on Insular Cortex: 3D Volumetric Analysis
(TÜBİTAK Scientific & Technological Research Council Turkey, 2021) Oz, Fatma; Acer, Niyazi; Katayifci, Nihan; Aytac, Gunes; Karaali, Kamil; Sindel, Muzaffer
Background/aim: The insula has attracted the attention of many neuroimaging studies because of its key role between brain structures. However, the number of studies investigating the effect of sex and laterality on insular volume is insufficient. The aim of this study was to investigate the differences in insular volume between sexes and hemispheres. Materials and methods: A total of 47 healthy participants [24 males (20.08 +/- 1.44 years) and 23 females (19.57 +/- 0.90 years)] underwent magnetic resonance imaging (MRI). Imaging was performed using the 3T MRI scanner. The insular volume was measured using the Individual Brain Atlases using Statistical Parametric Mapping (IBASPM); total intracranial, cerebral, grey and white matter volumes were measured using volBrain. Results: The right insular volume was significantly higher than the left insular volume in the participants, and the left cerebral volume was significantly higher than the right cerebral volume (p < 0.05). The total brain, total cerebral, left and right insular, and cerebral volumes were significantly larger in males than in females (p < 0.001). Also, the ratios of the insular volume to total brain and cerebral volume were significantly higher in males than in females (p < 0.05). Conclusion: This study shows that insular volume differs with laterality and sex. This outcome may be explained by the anatomical relationship between the insula and behavioural functions and emotional reactions and the fact that the right side of the brain is best at expressive and creative tasks.
Stereological Study on the Effect of Carnosine on of Purkinje Cells in the Cerebellum of Rats Exposed to 900 MHz Electromagnetic Field
(Turkish Neurosurgical Soc, 2022) Arslan, Ayla; Acer, Niyazi; Kesici, Hakan; Sonmez, Mehmet Fatih; Ertekin, Tolga; Gultekin, Murat; Saracoglu, Omer Galip
AIM: To evaluate the impact of carnosine on Purkinje neurons in rats exposed to a 900 Mhz electromagnetic field. MATERIAL and METHODS: This study evaluated 24 rats divided into the following three different groups: a control group, a group exposed to the electromagnetic field, and a group that was injected with carnosine while being exposed to the electromagnetic field. The electromagnetic field group was exposed to a 900 Mhz electromagnetic field for an hour daily over 28 days. Thereafter, stereological analysis was performed histologically on cerebellar sections, and the number of Purkinje cells were counted. RESULTS: The electromagnetic field group had remarkably fewer Purkinje cell compared to control. The electromagnetic field group plus 20 mg of carnosine had significantly more total Purkinje cells compared to the electromagnetic field group (p<0.05). CONCLUSION: The present study showed that electromagnetic field exposure decreases the number of Purkinje cell, whereas carnosine protected the cerebellum from neural damage induced by electromagnetic field exposure.
Structural and Functional Changes in the Brains of Guitarist Musicians: Volumetric, VBM, and Resting State fMRI Study
(Erciyes University School Medicine, 2024) Acer, Niyazi; Arpacay, Burcu Kamasak; Gray, Serap Bastepe; Karapinar, Burak Oguzhan; Ipekten, Funda; Degirmencioglu, Levent; Ilica, Ahmet Turan
Objective: Musicians acquire intricate motor and auditory skills from an early age, serving as an exemplary model for brain plasticity. This study aimed to investigate the structural and functional differences in the brains between guitar-playing musicians and non-musicians. Materials and Methods: Cortical thickness measurements, volumetric analysis of the corpus callosum and hippocampus, voxel-based morphometry (VBM), and resting-state functional magnetic resonance imaging (fMRI) were applied to a magnetic resonance imaging dataset from 14 male young adult guitar players and 10 matched non-musicians. Results: A structural asymmetry, mainly localized to hippocampal regions including the stratum radiatum, lacunosum, and moleculare, was found in the musicians' group. VBM analysis demonstrated increased volume in the frontal middle and inferior gyri (left), precuneus (right), insula (right), and Brodmann areas 7 and 13 in the musician group compared to non-musicians. There were no statistical differences between musicians and non-musicians in terms of corpus callosum and hippocampal subfield volumes. Although cortical thickness measured at different locations was higher in the musician group than in the non-musician group, these differences were not statistically significant (p>0.05). No significant functional connectivity alterations were found within the default mode network between musicians and non-musicians (p>0.05). Conclusion: Playing a musical instrument triggers rapid integration of multi-sensory information in the context of musical performance. The functional state of rest has contributed significantly to understanding musicians' brain networks.
A Volumetric Study of the Corpus Callosum in the Turkish Population
(Thieme Medical Publishing Inc, 2022) Soysal, Handan; Acer, Niyazi; Ozdemir, Meltem; Eraslan, Onder
Objective The aim of this study is to measure the average corpus callosum (CC) volume of healthy Turkish humans and to analyze the effects of gender and age on volumes, including the genu, truncus, and splenium parts of the CC. Patients and Methods Magnetic resonance imaging brain scans were obtained from 301 healthy male and female subjects, aged 11 to 84 years. The median age was 42 years (min-max: 11-82) in females and 49 years (min-max: 12-84) in males. Corpus callosum and its parts were calculated by using MRICloud. CC volumes of each subject were compared with those of the age and gender groups. Results All volumes of the CC were significantly higher in males than females. All left volumes except BCC were significantly higher than the right volumes in both males and females. The oldest two age groups (50-69 and 70-84 years) were found to have higher bilateral CC volumes, and bilateral BCC volumes were also higher than in the other two age groups (11-29 and 30-49 years). Conclusion The results suggest that compared with females/males, females have a faster decline in the volume of all volumes of the CC. We think that quantitative structural magnetic resonance data of the brain is vital in understanding human brain function and development.

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