PubMed İndeksli Yayınlar Koleksiyonu

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Betulinic Acid Isolated From Betula Platyphylla Induces Apoptosis and Reduces the mTOR/PI3K Signaling Pathway in Endometrial Cancer Cells
(2026) Akçal, Gözde Korkusuz; Oy, C.; Seçme, M.; Yurtseven, D.G.; Serter Kocoglu, S.S.
Endometrial cancer is one of the most common gynecological cancers worldwide, and an average of 42,000 women die each year. Chemotherapy, radiotherapy, and surgery are among the treatments available for endometrial cancer. Currently, drugs used for chemotherapy have had limited success in increasing the cure rate. Betulinic acid, a lupane-type triterpene widely found in the plant kingdom, has attracted attention for cancer treatment in recent years due to its ability to inhibit tumor growth and induce cell apoptosis. The aim of this study is to investigate the mTOR pathway-mediated anticancer effects of betulinic acid in human endometrial cancer cells. The effect of betulinic acid on Ishikawa cell viability was determined by the CCK-8 method. Its effect on the expression of genes involved in apoptosis and the mTOR pathway was assessed by real-time PCR. The effect on protein expression in the mTOR pathway was evaluated with immunohistochemistry and western blot, and the effects on apoptosis via Annexin V. Betulinic acid reduced Ishikawa endometrial cancer cell proliferation. Betulinic acid administration caused a significant decrease in Bcl2 (p=0.008) expression and increased caspase-8 (p=0.001) expression in Ishikawa cells. The results of Annexin V supported the idea that betulinic acid administration triggered apoptosis in Ishikawa cells. The mean rate of apoptotic cells in the betulinic acid group was 22±3.23%, while it was 2.31±0.2% in the control group (p=0.02). Betulinic acid caused a significant decrease in the expression of AKT1 (p=0.0001) and a significant increase in the expression of RAPTOR (p=0.00002). Betulinic acid administration also significantly decreased protein expression in the mTOR pathway. The percentage of p-PI3K, p-AKT, and p-mTOR-positive cells in Ishikawa cells was 89.39±5.19%, 74.84%±5.07, and 82.02%±6.14, respectively, in the control group. In the betulinic acid group, these values were 49.12±19.12% (p=0.002), 44.46±7.39% (p<0.001), and 53.70±8.94% (p<0.001), respectively. This study showed that betulinic acid decreased Ishikawa cell proliferation, triggered apoptosis, and decreased mTOR signaling; thus, betulinic acid may be a potential anticancer agent for the treatment of endometrial cancer. ©The Author(s) 2025. Open Access. This article is licensed under a Creative Commons CC-BY International License.
Missed Nursing Care in Cancer Units and Its Relationship With Cancer Nurses' Compassion Fatigue, Burnout, and Compassion Satisfaction: A Correlational Descriptive Study
(Elsevier Inc., 2025) Sarıbudak, T.P.; Yalçin, B.
Objectives: Cancer nurses face heavy workloads and emotional strain, making missed nursing care (MNC)—the omission or delay of necessary care—a growing concern, particularly in oncology settings in which patient vulnerability is high. While professional quality of life (ProQOL), including compassion fatigue (CF), burnout (BO), and compassion satisfaction (CS), is known to affect care quality, its link to MNC in cancer units remains underexplored.This study aimed to examine the extent of missed nursing care in cancer clinics, as well as how CF, BO, and CS influence MNC. Methods: A cross-sectional study was conducted with 147 nurses working in inpatient and outpatient oncology units in Türkiye. Data were collected via an online survey using the Professional Quality of Life Scale (ProQOL IV) and the Missed Nursing Care Survey. Analyses included descriptive statistics, nonparametric tests, correlation, and multiple linear regression. Results: Nurses reported moderate-to-high CF and BO, and low-to-moderate CS. The most frequently missed care practice was emotional support for patients and their families. Key reasons for MNC included staffing shortages and limited resources. No significant relationship was found between CF or BO and MNC. However, lower CS was significantly associated with higher MNC. Regression analysis showed that working in public hospitals and low perceived social support significantly predicted MNC. Conclusions: Missed nursing care is influenced by low CS, inadequate support, and challenging work environments, particularly in public hospitals. Implications for Nursing Practice: Enhancing compassion satisfaction and institutional support may reduce missed care and improve cancer care quality. © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Pragmatic Solutions to Reduce the Global Burden of Stroke: a World Stroke Organization–lancet Neurology Commission
(Elsevier Ltd, 2023) Feigin, V.L.; Owolabi, M.O.; Norrving, B.; Brainin, M.; Martins, S.; Pandian, J.; Dichgans, M.
Mindfulness-Based Self-Compassion and Vagal Nerve Stimulation Impact on Heart Rate Variability, Psychological Resilience, and Sleep Quality in Earthquake Survivors
(Routledge Journals, Taylor & Francis Ltd, 2026) Tonkus, Merve Bat; Dundar, Sule Okur; Dikici, Arzu; Alagoz, Ece; Caliskan, Behice Belkis
Earthquakes pose significant risks to both psychological and physiological health by disrupting autonomic regulation and increasing stress-related disorders. This study aims to evaluate the combined effects of Mindful Self-Compassion (MSC) and vagus nerve stimulation (VNS) on sleep quality, psychological resilience, and heart rate variability (HRV) in survivors of the February 2023 Turkey-Syria earthquakes. A randomized experimental study was conducted with 26 earthquake survivors, assigned to either a combined MSC+VNS group or a VNS-only group. The intervention lasted three weeks. Pre- and post-intervention assessments included the Pittsburgh Sleep Quality Index (PSQI), the Psychological Resilience Scale, and HRV parameters (RMSSD, pNN50, LF/HF ratio). Both groups showed improvement in sleep quality and resilience, with the MSC+VNS group demonstrating greater gains. Significant improvement was observed in LF/HF ratios in both groups, indicating enhanced autonomic balance. However, changes in RMSSD and pNN50 were not statistically significant. While VNS supports stress reduction, combining it with MSC yields stronger psychological and physiological benefits. These findings suggest that integrative approaches may be particularly effective in post-disaster recovery. Future studies with larger and more diverse samples are recommended to validate and expand on these results.
The Relationship Between Sustainable Earthquake Awareness and Coping Strategies for Earthquake Stress Among University Students: A Cross-Sectional Study
(Cambridge University Press, 2026) Gursoy, Zehra; Solmaz, Yasemin Cavus; Aksoy, Omer; Korfeci, Yusuf
Objective This study explores the relationship between sustainable earthquake awareness and earthquake stress coping strategies among university students following the February 6, 2023, earthquake.Methods A descriptive, cross-sectional study was conducted between March and April 2024, involving 239 university students. Following the STROBE checklist, data were collected using the Personal Information Form, Earthquake Stress Coping Scale (ESCS), and Sustainable Earthquake Awareness Scale (SEAS). Ethics approval was obtained, and data were gathered through face-to-face surveys.Results The average participant age was 21 years; 67.8% were women, and 20% had direct earthquake experience. Among participants, 67.4% reported negative academic impacts due to the earthquake. Higher SEAS scores were associated with higher income, prior earthquake experiences, having an emergency kit, securing belongings, and participation in earthquake training and drills. Higher ESCS social support-seeking scores correlated with higher income, earthquake preparedness training, drill participation, awareness of emergency meeting areas, and enrollment in the child development department.Conclusion The findings highlight gaps in earthquake preparedness among university students while emphasizing the role of personal earthquake experiences in fostering awareness and adaptive coping strategies. Enhancing earthquake preparedness training could improve resilience among students in earthquake-prone regions.
The Role of Trust and Happiness in the Relationship Between Organizational Ostracism and Turnover Intentions Among Healthcare Professionals: A Serial Mediation Model
(BMC, 2026) Kopuz, Koray; Ozisli, Omer; Ekmen, Eymen; Kocak, Orhan
Background Organizational ostracism is an important yet often overlooked factor affecting healthcare professionals' well-being and retention. Guided by Social Exchange Theory and Affective Events Theory, this study examines how negative workplace interactions, such as ostracism, trigger interconnected cognitive (organizational trust) and affective (happiness at work) processes that shape turnover intention. The research focuses on understanding the link between organizational ostracism and turnover intention, emphasizing the sequential mediating roles of organizational trust (cognitive) and happiness at work (affective). Methods This cross-sectional study surveyed 403 healthcare professionals working in four large public hospitals in T & uuml;rkiye, recruited through convenience sampling. Data were collected online using SurveyMonkey and analyzed with SPSS version 23 and AMOS version 23. Descriptive statistics, confirmatory factor analysis (CFA), and path analysis were performed, and mediation effects were tested using bias-corrected bootstrapping with 5,000 resamples and 95% confidence intervals (CIs). Results Organizational ostracism was positively associated with turnover intention. When organizational trust and happiness at work were added as mediators, the direct link between organizational ostracism and turnover intention became non-significant, indicating a full mediation model. Organizational ostracism negatively influenced organizational trust and happiness at work, and both variables played significant roles in explaining turnover intention. Consistent with the cognitive-affective framework, sequential mediation analysis showed that reduced organizational trust contributed to lower happiness at work, further amplifying turnover intention. Conclusions Organizational trust and happiness at work are critical mechanisms linking organizational ostracism to turnover intention. Addressing ostracism and fostering supportive, trust-based work environments can help reduce turnover risk and strengthen healthcare teams. These findings provide actionable guidance for healthcare leaders and emphasize the importance of addressing workplace exclusion to enhance workforce stability and team effectiveness.
Suicide Risk and Influencing Factors Among Cancer Patients: A Mixed-Methods Study
(Elsevier Sci Ltd, 2026) Saribudak, Tugba Pehlivan; Ustun, Besti; Cihan, Servet; Yildirim, Berna
Purpose: Suicide probability is higher in cancer patients than in the general population, yet evidence remains limited, especially in T & uuml;rkiye. This study examined suicide risk and influencing factors using a mixed-methods approach for a comprehensive understanding. Methods: This sequential explanatory mixed-methods design was conducted between October 2024-August 2025. 383 patients receiving chemotherapy for breast, lung, or colon cancer at a city hospital in I(center dot)stanbul participated. Quantitative data were collected using a Personal Information Form and the Suicide Probability Scale, and analyzed using multistage linear regression. For the qualitative phase, patients with the highest and lowest scores were purposively sampled, and data were analyzed using Colaizzi's method. Results: The mean Suicide Probability Scale score was 63.13. Regression analysis identified lower social support, longer cancer duration, lack of health insurance, and psychiatric comorbidities as predictors of higher risk. Qualitative analysis yielded five themes. The dominant themes-'Traces of the Disease' and 'Risk and Protective Factors'-showed how cancer's physical, psychological, and social consequences, together with individual risk and protective mechanisms, shaped patients' suicidal thoughts, behavior, overall distress, and resilience levels. Conclusions: Suicide risk in cancer patients is multidimensional and individualized, shaped by social, clinical, and psychological factors. Holistic support addressing both risk and protective factors is critical. Oncology nurses are pivotal in early risk detection and psychosocial support. Empathetic, patient-centered care, reinforcing protective factors, and integrating structured psychological interventions enhance resilience, reduce suicide risk, and improve quality of life. System-level measures, including accessible psychological services and social support, are also essential.
Citation - WoS: 11
Citation - Scopus: 15
Automated Segmentation of the Injured Spleen
(Springer Heidelberg, 2016) Dandin, Ozgur; Teomete, Uygar; Osman, Onur; Tulum, Gokalp; Ergin, Tuncer; Sabuncuoglu, Mehmet Zafer
Purpose To develop a novel automated method for segmentation of the injured spleen using morphological properties following abdominal trauma. Average attenuation of a normal spleen in computed tomography (CT) does not vary significantly between subjects. However, in the case of solid organ injury, the shape and attenuation of the spleen on CT may vary depending on the time and severity of the injury. Timely assessment of the severity and extent of the injury is of vital importance in the setting of trauma. Methods We developed an automated computer-aided method for segmenting the injured spleen from CT scans of patients who had splenectomy due to abdominal trauma. We used ten subjects to train our computer-aided diagnosis (CAD) method. To validate the CAD method, we used twenty subjects in our testing group. Probabilistic atlases of the spleens were created usingmanually segmented data from ten CT scans. The organ location was modeled based on the position of the spleen with respect to the left side of the spine followed by the extraction of shape features. We performed the spleen segmentation in three steps. First, we created a mask of the spleen, and then we used this mask to segment the spleen. The third and final step was the estimation of the spleen edges in the presence of an injury such as laceration or hematoma. Results The traumatized spleens were segmented with a high degree of agreement with the radiologist-drawn contours. The spleen quantification led to 86 +/- 5% volume overlap, 92.5 +/- 3.11% Dice similarity index, 89.05 +/- 5.29%/96.42 +/- 2.55 precision/sensitivity, 8 +/- 5% volume estimation error rate, 1.09 +/- 0.62/1.91 +/- 1.45mm average surface distance/root-mean-squared error. Conclusions OurCADmethod robustly segments the spleen in the presence of morphological changes such as laceration, contusion, pseudoaneurysm, active bleeding, periorgan and parenchymal hematoma, including subcapsular hematoma due to abdominal trauma. CAD of the splenic injury due to abdominal trauma can assist in rapid diagnosis and assessment and guide clinical management. Our segmentation method is a general framework that can be adapted to segment other injured solid abdominal organs.
Citation - WoS: 2
Citation - Scopus: 3
Rule-Based Fuzzy Classifier for Spinal Deformities
(IOS Press, 2014) Birtane, Sibel; Korkmaz, Hayriye
In this paper, 2-steps software using image processing and enhancement technologies is developed to obtain a scoliosis patient's spine pattern from 2D coronal X-Ray images without manual land marking. Then, a Rule-based Fuzzy classifier is implemented on those images to classify the spine patterns using the King-Moe classification approach.
Citation - WoS: 16
Citation - Scopus: 21
Celiac Disease and COVID-19 Pandemic: Should We Worry?
(Univ Catholique Louvain-UCL, 2020) Gokden, Y.; Hot, S.; Adas, M.; Koc, D. Ogutmen; Atak, S.; Hot, A. B.
Background and study aims : The Coronavirus Disease 2019 (COVID-19) epidemic especially worries people with chronic diseases the entire world. In this study, the frequency, and clinical course of COVID-19 infection in patients with Celiac disease (CD) were investigated. CD patients' adherence to purchasing gluten free products (GFPs), the strict diet, and how patients' anxiety affects CD symptoms during the COVID-19 outbreak were also examined. Patients and methods : A detailed-questionnaire was administered by telephone, and e-mail to the CD patients to determine the status of these patients in obtaining GFPs, and dietary compliance during the COVID-19 pandemic. State and trait anxiety levels of patients were evaluated using the State-trait Anxiety Inventory- (STAI) scale. Additionally, whether patients with CD were diagnosed with COVID-19, and if diagnosed, their clinical course of the disease were investigated. Results : One hundred and one patients were included in the study. The total number of patients who could obtain GFPs decreased significantly in the pandemic than before the pandemic. The patients' state anxiety index was 40.7 +/- 7.9, and the trait anxiety index was 44.5 +/- 8.5, and all patients were evaluated as mildly anxious. During the pandemic, two female patients were diagnosed with COVID-19. Conclusion : CD patients did not have any additional risk compared to other individuals in terms of becoming infected with COVID-19 for patients under gluten free diet, and these patients will have a similar clinical course as individuals without CD.
Citation - WoS: 2
Citation - Scopus: 4
A Common VWF Exon 28 Haplotype in the Turkish Population
(Sage Publications Inc, 2013) Berber, Ergul; Pehlevan, Funda; Akin, Mehmet; Capan, Ozlem Yalcin; Kavakli, Kaan; Caglayan, S. Hande
An increasing number of mutations and polymorphisms have been identified in the von Willebrand factor (VWF) gene of patients with von Willebrand disease (VWD). Most of the sequence alterations are within exon 28, duplicated in the VWF pseudogene on chromosome 22. Genetic recombination causing the gene conversion between the VWF gene and its pseudogene is associated with multiple substitutions in the VWF gene and with VWD. In the present study, VWF gene exon 28 was analyzed in 33 patients with VWD by DNA sequencing. A total of 73% of the patients were heterozygous for p.D1472H, p.V1485L, p.1500A, p.1501F, p.L1503P, and p.S1506L single-nucleotide polymorphisms. Family analysis revealed that the gene conversion occurred between the VWF gene and its pseudogene in 3 patients. Case-control association analysis by Haploview 4.2 did not show an association between the haplotype and VWD. In conclusion, a common exon 28 haplotype in the Turkish population, which might have arisen from the gene conversion events in the founder population, was identified.
Citation - WoS: 10
Citation - Scopus: 12
Nanostructured Biomaterials with Antimicrobial Properties
(Bentham Science Publ Ltd, 2014) Sahin, Yesim Muge; Yetmez, Mehmet; Oktar, Faik N.; Gunduz, Oguzhan; Agathopoulos, Simeon; Andronescu, Ecaterina; Ficai, Anton
The present review is intended to bring together the main advances in the field of nanostructured biomaterials with antimicrobial properties. It is generally accepted that the discovery of antibiotics was of great importance but, nowadays new antimicrobial agents are needed and/or their better administration routes. The limitation of the use of antibiotics is essential because of the following reasons: the excessive use of antibiotics leads to the development of antibiotic resistant microorganisms; there are some alternatives for many types of infections, many of these alternatives being less toxic and do not lead to antibiotic similar resistance. In compliance with the above presented, the use of antibiotic is recommended to be eliminated (when alternatives are available) or to be reduced by using combined therapy when possible or to administrate these drugs through targeted or loco-regional drug delivery systems.
Citation - WoS: 1
Citation - Scopus: 1
Effects of Menstrual Symptoms on Dietary Intake Frequency
(Elsevier Science Inc, 2025) Akturk, Nur Bahar Kuru; Kolcu, Merve; Yilmaz, Aydan
Introduction and Objective: The symptoms that are seen due to changes in hormone levels during menstruation may lead to changes in the dietary intake frequency and eating behaviors of women. This study was conducted to determine the effects of menstrual symptoms on changes in the dietary intake frequency of women. Method: The data of this descriptive study were collected between May and June 2024 from 393 women aged 18-45 who had regular menstruation and were selected by snowball sampling using an online survey. A Descriptive Information Form, the Menstrual Symptoms Questionnaire and the Nutrition Consumption Frequency Change Scale of Change were used to collect data. Descriptive statistics, paired-samples t-tests, and multiple regression analysis were used to analyze the data. Results: The participants had significantly higher dietary intake levels of traditional beverages and dietary supplements during menstruation in comparison to before menstruation (P < 0.001). Menstrual symptoms were identified as factors that significantly affected the intake of traditional beverages and dietary supplements by the participants, as well as their overall dietary intake. Conclusion: Menstrual symptoms of women significantly affected their intake of traditional beverages, intake of dietary supplements, and general dietary intake during menstruation.
(c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Citation - WoS: 33
Citation - Scopus: 43
A Novel Method for Pulmonary Embolism Detection in CTA Images
(Elsevier Ireland Ltd, 2014) Ozkan, Haydar; Osman, Onur; Sahin, Sinan; Boz, Ali Fuat
In this paper, we propose a new computer-aided detection (CAD) - based method to detect pulmonary embolism (PE) in computed tomography angiography images (CTAI). Since lung vessel segmentation is the main objective to provide high sensitivity in PE detection, this method performs accurate lung vessel segmentation. To concatenate clogged vessels due to PEs, the starting region of PEs and some reference points (RPs) are determined. These RPs are detected according to the fixed anatomical structures. After lung vessel tree is segmented, the region, intensity, and size of PEs are used to distinguish them. We used the data sets that have heart disease or abnormal tissues because of lung disease except PE in this work. According to the results, 428 of 450 PEs, labeled by the radiologists from 33 patients, have been detected. The sensitivity of the developed system is 95.1% at 14.4 false positive per data set (FP/ds). With this performance, the proposed CAD system is found quite useful to use as a second reader by the radiologists. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
Citation - WoS: 2
Foreign Body Aspirations in Childhood: A Retrospective Review
(Elsevier Science inc, 2023) Ekim, Ayfer; Altun, Aslihan
Objective: The aim of this study was to examine the childhood-age foreign body aspiration (FBA) retrospectively by focusing on symptoms, types, home interventions, hospitalization and complications. Method: All patients between 0-18 years admitted to pediatric surgical clinic and diagnosed with FBA were ex-amined retrospectively from January 2021 to January 2022. Results: The study group consisted of 163 patients and their mean age was 17.8 +/- 12.7 months (1 months to 6 years). FBA events included aspiration of food (78%), coins (10%), batteries (3.7%), parts of toys (4%), buttons (2.4%) and other (2%). First aid treatment to children was performed at home by mothers (61%). Types of first aid treatment performed by mothers included tapping the back (31%); cleaning inside the mouth (24%); trying to remove the foreign body with fingers (12%), pushing the foreign body forward (5.9%) and forcing the child to vomit (9.5%) respectively. Conclusions: FBA isa potential life-threatening health problem during childhood. When the age of majority of pa-tients being under one year old and prevalence of food in FBA types are taken into consideration, safe-feeding practices of mothers, feeding position and training about the safe-environment are the basic steps of prevention strategies. Practice implications: One of the most useful ways of preventing FBA cases is to provide planned and continuing education to parents, care givers and all the individuals responsible for the care of the child in order to increase their knowledge and practice levels. (c) 2023 Elsevier Inc. All rights reserved.
Citation - WoS: 2
Evaluating the Brainstem in Children With Breathholding Spells
(Kare Publishing, 2022) Özçora, G.D.K.; Kumandaš, S.; Saǧiroǧlu, A.; Acer, N.; Doǧanay, S.; Yiğit, H.; Gümüş, H.
OBJECTIVE: Breath-holding spells (BHSs) are a non-epileptic paroxysmal phenomenon characterized by frequent apnea episodes, loss of consciousness, and changes in skin tone and postural tone triggered by negative stimuli of childhood. The pathophysiology of the disease remains unclear; autonomic dysregulation caused by delayed myelination is believed to play a role. In this study, we aimed to evaluate the brainstems of children with BHS using diffusion tensor imaging (DTI) and investigate the etiology of this phenomenon. METHODS: The study group consisted of 16 children with a history of severe breath-holding episodes (accompanied by loss of consciousness and tonic contraction due to prolonged anoxic response) and 18 age-, gender-, and handedness-matched controls. All children underwent systemic, neurologic, and cardiologic evaluation, including complete blood count, blood biochemistry, serum iron and ferritin level, serum vitamin B12 level, electrocardiogram, and electroencephalograms. Magnetic resonance imaging was performed using a 1.5-Tesla Siemens Aera scanner (Siemens, Germany). RESULTS: Evaluation of brainstem (midbrain, pons, and medulla oblongata) volumes revealed no statistically significant differences between the BHS patient and control groups. In a voxel-wise analysis of DTI data, the BHS patient group had significantly lower fractional anisotropy (FA) values than the control group in the bilateral midbrain and medulla, right corticospinal tract, bilateral corpus callosum body and splenium, and left corpus callosum genu. In contrast, there were no significant differences in FA values in the pons, cerebellum, left corticospinal tract, and right corpus callosum genu. CONCLUSION: Based on our findings, we think that patients with BHS should be treated with an approach similar to other neurodevelopmental diseases and that this study may help elucidate the pathophysiology and establish the groundwork for future studies on its treatment. © 2022 by Istanbul Provincial Directorate of Health.
Citation - Scopus: 5
Expression of Genes Related to Iron Homeostasis in Breast Cancer
(Springer Science and Business Media B.V., 2023) Mutlu, T.; Özoran, E.; Trabulus, D.C.; Kelten, C.K.; Erhan, D.; Mete, M.; Guven, M.
Background: The dysfunctions in the metabolism of iron have an important role in many pathological conditions, ranging from disease with iron deposition to cancer. Studies on malignant diseases of the breast reported irregular expression in genes associated with iron metabolism. The variations are related to findings that have prognostic significance. This study evaluated the relationship of the expression levels of transferrin receptor 1 (TFRC), iron regulatory protein 1 (IRP1), hepcidin (HAMP), ferroportin 1 (FPN1), hemojuvelin (HFE2), matriptase 2 (TMPRSS6), and miR-122 genes in the normal and malignant tissues of breast cancer patients. Methods & Results: The normal and malignant tissues from 75 women with breast malignancies were used in this study. The patients did not receive any treatment previously. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used in figuring the levels of gene expression associated with iron metabolism. When the malignant and normal tissues gene expression levels were analyzed, expression of TFRC increased (1.586-fold); IRP1 (0.594 fold) and miR-122 (0.320 fold) expression decreased; HAMP, FPN1, HFE2, and TMPRSS6 expressions did not change. FPN1 and IRP1 had a positive association, and this association was statistically significant (r = 0.266; p = 0.022). IRP1 and miR-122 had a positive association, and this association had statistical significance (r = 0.231; p = 0.048). Conclusions: Our study portrayed the important association between genes involved in iron hemostasis and breast malignancy. The results could be used to establish new diagnostic techniques in the management of breast malignancies. The alterations in the metabolism of malignant breast cells with normal breast cells could be utilized to achieve advantages in treatment. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.
Self-Induced Nail Disorders: Clinical and Demographical Features
(Wiley, 2025) Dogruel, Gaye Guldiken; Atis, Guldehan; Esen, Mustafa; Demirbas, Gozde Ulutas; Guldogan, Ozge; Demirbas, Abdullah; Goktay, Fatih
BackgroundSelf-induced nail disorders (SINDs) are a subset of body-focused repetitive behaviors (BFRBs) characterized by pathological grooming habits that damage the nail and periungual structures. These disorders were classified into subgroups based on the specific methods individuals use to harm their nails. Despite their prevalence and potential psychological impact, limited data exist. This study aims to investigate the demographic and clinical characteristics of SINDs.MethodsThis multicenter prospective cohort study included 675 patients diagnosed with SINDs at dermatology outpatient clinics between February and June 2024. Data collected included demographic information, SIND subtypes, associated BFRBs, psychiatric history, and family history of BFRBs. Patients were categorized into six SIND subgroups. Approval from the ethical committee was obtained.ResultsThe mean age of SIND onset was 16.60 +/- 10.61 years, with no significant gender difference (p = 0.195). Forty-seven percent of patients belonged to more than one SIND subgroup, and 45.4% had other BFRBs, with cheek/lip biting (55.7%) and acne excori & eacute;e (44.9%) being the most common. Females exhibited higher rates of accompanying BFRBs (54.5% vs. 31.2%; p = 0.001). Patients rarely sought medical treatment (19.1%), even if they felt severe discomfort regarding their habit (56.0%). Patients with diagnosed psychiatric disorders or a family history of BFRBs were more likely to seek treatment (p = 0.001, p = 0.013).ConclusionSINDs often coexist with other BFRBs, predominantly affecting females. While patients are frequently aware of their habits, the rate of seeking medical treatment remains low. Dermatologists play a vital role in identifying SINDs, addressing associated behaviors, and coordinating care for coexisting psychiatric conditions.
Citation - WoS: 1
Psychopathologic Evaluation in Patients with Nasal Bone Fractures
(Sage Publications Inc, 2024) Demir, Songul; Akbudak, M. Mahir; Sizer, Bilal
Background: Nasal bone fractures are pretty common. The most common causes include interpersonal violence, traffic accidents, sports injuries, and falls. This study aimed to assess patients presenting with nasal bone fractures not only for nasal trauma but also for personality disorders, impulsivity, and attention-deficit/hyperactivity disorder (ADHD) using psychiatric questionnaires. Methods: The study included 41 patients, and the control group consisted of 43 volunteers without nasal bone fracture; neither the patients nor the volunteers had previously been diagnosed with or treated for psychiatric disorders. The psychiatric questionnaires administered were the Eysenck Personality Questionnaire Revised-Short Form (EPQR-S), the Barratt Impulsivity Scale-Short Form (BIS-11-SF), and Turgay's Adult ADD/ADHD DSM-IV-based Scale. Results: The most common cause of nasal bone fractures in our study was violence (41.5%), followed by traffic accidents (29.3%), falls (17%), and sports injuries (12.2%). In the EPQR-S assessment, the nasal bone fracture (NBF) group had significantly-higher total scores than the control group (CG) (P < .001). In the subscales of the questionnaire, extroversion, psychoticism, and lie subscale scores were higher in the NBF group than in the CG. In the BIS-11-SF assessment, the NBF group had higher total scores than the CG (P < .001). Assessment using Turgay's adult ADD/ADHD DSM IV-based diagnostic screening and rating scale revealed no statistically-significant difference between the NBF group and the CG in terms of attention deficit and hyperactivity. Conclusion: We found that psychoticism patterns and impulsivity were more prevalent in the patient group, whereas ADD/ADHD was not. The results of our study suggest that performing a psychiatric assessment may be the right decision in patients presenting with NBFs caused by violence, whether they are the aggressor or the victim.
Citation - WoS: 13
Mechanisms of Peptide Hydrolysis by Aspartyl and Metalloproteases
(Royal Society of Chemistry, 2016) Paul, Thomas J.; Barman, Arghya; Ozbil, Mehmet; Bora, Ram Prasad; Zhang, Tingting; Sharma, Gaurav; Prabhakar, Rajeev
Peptide hydrolysis has been involved in a wide range of biological, biotechnological, and industrial applications. In this perspective, the mechanisms of three distinct peptide bond cleaving enzymes, beta secretase (BACE1), insulin degrading enzyme (IDE), and bovine lens leucine aminopeptidase (BILAP), have been discussed. BACE1 is a catalytic Asp dyad [Asp, Asp(-)] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively. Specifically, enzyme-substrate interactions and the roles of metal ion(s), the ligand environment, second coordination shell residues, and the protein environment in the functioning of these enzymes have been elucidated. This information will be useful to design small inhibitors, activators, and synthetic analogues of these enzymes for biomedical, biotechnological, and industrial applications.

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