PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12294/2425

Browse

Now showing 1 - 20 of 634

Letter to the Editor: Posterior Epidural Migration of Lumbar Intervertebral Disc Fragment
(American Association of Neurological Surgeons jnevro@virginia.edu, 2015) Şengöz, A.; Kotil, K.; Taşdemiroǧlu, E.
[No abstract available]
Citation - WoS: 11
Citation - Scopus: 15
Automated Segmentation of the Injured Spleen
(Springer Heidelberg, 2016) Dandin, Ozgur; Teomete, Uygar; Osman, Onur; Tulum, Gokalp; Ergin, Tuncer; Sabuncuoglu, Mehmet Zafer
Purpose To develop a novel automated method for segmentation of the injured spleen using morphological properties following abdominal trauma. Average attenuation of a normal spleen in computed tomography (CT) does not vary significantly between subjects. However, in the case of solid organ injury, the shape and attenuation of the spleen on CT may vary depending on the time and severity of the injury. Timely assessment of the severity and extent of the injury is of vital importance in the setting of trauma. Methods We developed an automated computer-aided method for segmenting the injured spleen from CT scans of patients who had splenectomy due to abdominal trauma. We used ten subjects to train our computer-aided diagnosis (CAD) method. To validate the CAD method, we used twenty subjects in our testing group. Probabilistic atlases of the spleens were created usingmanually segmented data from ten CT scans. The organ location was modeled based on the position of the spleen with respect to the left side of the spine followed by the extraction of shape features. We performed the spleen segmentation in three steps. First, we created a mask of the spleen, and then we used this mask to segment the spleen. The third and final step was the estimation of the spleen edges in the presence of an injury such as laceration or hematoma. Results The traumatized spleens were segmented with a high degree of agreement with the radiologist-drawn contours. The spleen quantification led to 86 +/- 5% volume overlap, 92.5 +/- 3.11% Dice similarity index, 89.05 +/- 5.29%/96.42 +/- 2.55 precision/sensitivity, 8 +/- 5% volume estimation error rate, 1.09 +/- 0.62/1.91 +/- 1.45mm average surface distance/root-mean-squared error. Conclusions OurCADmethod robustly segments the spleen in the presence of morphological changes such as laceration, contusion, pseudoaneurysm, active bleeding, periorgan and parenchymal hematoma, including subcapsular hematoma due to abdominal trauma. CAD of the splenic injury due to abdominal trauma can assist in rapid diagnosis and assessment and guide clinical management. Our segmentation method is a general framework that can be adapted to segment other injured solid abdominal organs.
Citation - WoS: 2
Citation - Scopus: 3
Rule-Based Fuzzy Classifier for Spinal Deformities
(IOS Press, 2014) Birtane, Sibel; Korkmaz, Hayriye
In this paper, 2-steps software using image processing and enhancement technologies is developed to obtain a scoliosis patient's spine pattern from 2D coronal X-Ray images without manual land marking. Then, a Rule-based Fuzzy classifier is implemented on those images to classify the spine patterns using the King-Moe classification approach.
Citation - WoS: 16
Citation - Scopus: 21
Celiac Disease and COVID-19 Pandemic: Should We Worry?
(Univ Catholique Louvain-UCL, 2020) Gokden, Y.; Hot, S.; Adas, M.; Koc, D. Ogutmen; Atak, S.; Hot, A. B.
Background and study aims : The Coronavirus Disease 2019 (COVID-19) epidemic especially worries people with chronic diseases the entire world. In this study, the frequency, and clinical course of COVID-19 infection in patients with Celiac disease (CD) were investigated. CD patients' adherence to purchasing gluten free products (GFPs), the strict diet, and how patients' anxiety affects CD symptoms during the COVID-19 outbreak were also examined. Patients and methods : A detailed-questionnaire was administered by telephone, and e-mail to the CD patients to determine the status of these patients in obtaining GFPs, and dietary compliance during the COVID-19 pandemic. State and trait anxiety levels of patients were evaluated using the State-trait Anxiety Inventory- (STAI) scale. Additionally, whether patients with CD were diagnosed with COVID-19, and if diagnosed, their clinical course of the disease were investigated. Results : One hundred and one patients were included in the study. The total number of patients who could obtain GFPs decreased significantly in the pandemic than before the pandemic. The patients' state anxiety index was 40.7 +/- 7.9, and the trait anxiety index was 44.5 +/- 8.5, and all patients were evaluated as mildly anxious. During the pandemic, two female patients were diagnosed with COVID-19. Conclusion : CD patients did not have any additional risk compared to other individuals in terms of becoming infected with COVID-19 for patients under gluten free diet, and these patients will have a similar clinical course as individuals without CD.
Citation - WoS: 2
Citation - Scopus: 4
A Common VWF Exon 28 Haplotype in the Turkish Population
(Sage Publications Inc, 2013) Berber, Ergul; Pehlevan, Funda; Akin, Mehmet; Capan, Ozlem Yalcin; Kavakli, Kaan; Caglayan, S. Hande
An increasing number of mutations and polymorphisms have been identified in the von Willebrand factor (VWF) gene of patients with von Willebrand disease (VWD). Most of the sequence alterations are within exon 28, duplicated in the VWF pseudogene on chromosome 22. Genetic recombination causing the gene conversion between the VWF gene and its pseudogene is associated with multiple substitutions in the VWF gene and with VWD. In the present study, VWF gene exon 28 was analyzed in 33 patients with VWD by DNA sequencing. A total of 73% of the patients were heterozygous for p.D1472H, p.V1485L, p.1500A, p.1501F, p.L1503P, and p.S1506L single-nucleotide polymorphisms. Family analysis revealed that the gene conversion occurred between the VWF gene and its pseudogene in 3 patients. Case-control association analysis by Haploview 4.2 did not show an association between the haplotype and VWD. In conclusion, a common exon 28 haplotype in the Turkish population, which might have arisen from the gene conversion events in the founder population, was identified.
Citation - WoS: 10
Citation - Scopus: 12
Nanostructured Biomaterials with Antimicrobial Properties
(Bentham Science Publ Ltd, 2014) Sahin, Yesim Muge; Yetmez, Mehmet; Oktar, Faik N.; Gunduz, Oguzhan; Agathopoulos, Simeon; Andronescu, Ecaterina; Ficai, Anton
The present review is intended to bring together the main advances in the field of nanostructured biomaterials with antimicrobial properties. It is generally accepted that the discovery of antibiotics was of great importance but, nowadays new antimicrobial agents are needed and/or their better administration routes. The limitation of the use of antibiotics is essential because of the following reasons: the excessive use of antibiotics leads to the development of antibiotic resistant microorganisms; there are some alternatives for many types of infections, many of these alternatives being less toxic and do not lead to antibiotic similar resistance. In compliance with the above presented, the use of antibiotic is recommended to be eliminated (when alternatives are available) or to be reduced by using combined therapy when possible or to administrate these drugs through targeted or loco-regional drug delivery systems.
Citation - WoS: 1
Citation - Scopus: 1
Effects of Menstrual Symptoms on Dietary Intake Frequency
(Elsevier Science Inc, 2025) Akturk, Nur Bahar Kuru; Kolcu, Merve; Yilmaz, Aydan
Introduction and Objective: The symptoms that are seen due to changes in hormone levels during menstruation may lead to changes in the dietary intake frequency and eating behaviors of women. This study was conducted to determine the effects of menstrual symptoms on changes in the dietary intake frequency of women. Method: The data of this descriptive study were collected between May and June 2024 from 393 women aged 18-45 who had regular menstruation and were selected by snowball sampling using an online survey. A Descriptive Information Form, the Menstrual Symptoms Questionnaire and the Nutrition Consumption Frequency Change Scale of Change were used to collect data. Descriptive statistics, paired-samples t-tests, and multiple regression analysis were used to analyze the data. Results: The participants had significantly higher dietary intake levels of traditional beverages and dietary supplements during menstruation in comparison to before menstruation (P < 0.001). Menstrual symptoms were identified as factors that significantly affected the intake of traditional beverages and dietary supplements by the participants, as well as their overall dietary intake. Conclusion: Menstrual symptoms of women significantly affected their intake of traditional beverages, intake of dietary supplements, and general dietary intake during menstruation.
(c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Citation - WoS: 33
Citation - Scopus: 43
A Novel Method for Pulmonary Embolism Detection in CTA Images
(Elsevier Ireland Ltd, 2014) Ozkan, Haydar; Osman, Onur; Sahin, Sinan; Boz, Ali Fuat
In this paper, we propose a new computer-aided detection (CAD) - based method to detect pulmonary embolism (PE) in computed tomography angiography images (CTAI). Since lung vessel segmentation is the main objective to provide high sensitivity in PE detection, this method performs accurate lung vessel segmentation. To concatenate clogged vessels due to PEs, the starting region of PEs and some reference points (RPs) are determined. These RPs are detected according to the fixed anatomical structures. After lung vessel tree is segmented, the region, intensity, and size of PEs are used to distinguish them. We used the data sets that have heart disease or abnormal tissues because of lung disease except PE in this work. According to the results, 428 of 450 PEs, labeled by the radiologists from 33 patients, have been detected. The sensitivity of the developed system is 95.1% at 14.4 false positive per data set (FP/ds). With this performance, the proposed CAD system is found quite useful to use as a second reader by the radiologists. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
Citation - WoS: 2
Foreign Body Aspirations in Childhood: A Retrospective Review
(Elsevier Science inc, 2023) Ekim, Ayfer; Altun, Aslihan
Objective: The aim of this study was to examine the childhood-age foreign body aspiration (FBA) retrospectively by focusing on symptoms, types, home interventions, hospitalization and complications. Method: All patients between 0-18 years admitted to pediatric surgical clinic and diagnosed with FBA were ex-amined retrospectively from January 2021 to January 2022. Results: The study group consisted of 163 patients and their mean age was 17.8 +/- 12.7 months (1 months to 6 years). FBA events included aspiration of food (78%), coins (10%), batteries (3.7%), parts of toys (4%), buttons (2.4%) and other (2%). First aid treatment to children was performed at home by mothers (61%). Types of first aid treatment performed by mothers included tapping the back (31%); cleaning inside the mouth (24%); trying to remove the foreign body with fingers (12%), pushing the foreign body forward (5.9%) and forcing the child to vomit (9.5%) respectively. Conclusions: FBA isa potential life-threatening health problem during childhood. When the age of majority of pa-tients being under one year old and prevalence of food in FBA types are taken into consideration, safe-feeding practices of mothers, feeding position and training about the safe-environment are the basic steps of prevention strategies. Practice implications: One of the most useful ways of preventing FBA cases is to provide planned and continuing education to parents, care givers and all the individuals responsible for the care of the child in order to increase their knowledge and practice levels. (c) 2023 Elsevier Inc. All rights reserved.
Citation - WoS: 2
Evaluating the Brainstem in Children with Breathholding Spells
(Kare Publ, 2022) Ozcora, Gul Demet Kaya; Kumandas, Sefer; Sagiroglu, Ayse; Acer, Niyazi; Doganay, Selim; Yigit, Huseyin; Gumus, Hakan
OBJECTIVE: Breath-holding spells (BHSs) are a non-epileptic paroxysmal phenomenon characterized by frequent apnea episodes, loss of consciousness, and changes in skin tone and postural tone triggered by negative stimuli of childhood. The pathophysiology of the disease remains unclear; autonomic dysregulation caused by delayed myelination is believed to play a role. In this study, we aimed to evaluate the brainstems of children with BHS using diffusion tensor imaging (DTI) and investigate the etiology of this phenomenon. METHODS: The study group consisted of 16 children with a history of severe breath-holding episodes (accompanied by loss of consciousness and tonic contraction due to prolonged anoxic response) and 18 age-, gender-, and handedness-matched controls. All children underwent systemic, neurologic, and cardiologic evaluation, including complete blood count, blood bio-chemistry, serum iron and ferritin level, serum vitamin B12 level, electrocardiogram, and electroencephalograms. Magnetic resonance imaging was performed using a 1.5-Tesla Siemens Aera scanner (Siemens, Germany). RESULTS: Evaluation of brainstem (midbrain, pons, and medulla oblongata) volumes revealed no statistically significant differences between the BHS patient and control groups. In a voxel-wise analysis of DTI data, the BHS patient group had significantly lower fractional anisotropy (FA) values than the control group in the bilateral midbrain and medulla, right cortico-spinal tract, bilateral corpus callosum body and splenium, and left corpus callosum genu. In contrast, there were no significant differences in FA values in the pons, cerebellum, left corticospinal tract, and right corpus callosum genu. CONCLUSION: Based on our findings, we think that patients with BHS should be treated with an approach similar to other neurodevelopmental diseases and that this study may help elucidate the pathophysiology and establish the groundwork for future studies on its treatment.
Citation - Scopus: 5
Expression of Genes Related to Iron Homeostasis in Breast Cancer
(Springer Science and Business Media B.V., 2023) Mutlu, T.; Özoran, E.; Trabulus, D.C.; Kelten, C.K.; Erhan, D.; Mete, M.; Guven, M.
Background: The dysfunctions in the metabolism of iron have an important role in many pathological conditions, ranging from disease with iron deposition to cancer. Studies on malignant diseases of the breast reported irregular expression in genes associated with iron metabolism. The variations are related to findings that have prognostic significance. This study evaluated the relationship of the expression levels of transferrin receptor 1 (TFRC), iron regulatory protein 1 (IRP1), hepcidin (HAMP), ferroportin 1 (FPN1), hemojuvelin (HFE2), matriptase 2 (TMPRSS6), and miR-122 genes in the normal and malignant tissues of breast cancer patients. Methods & Results: The normal and malignant tissues from 75 women with breast malignancies were used in this study. The patients did not receive any treatment previously. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used in figuring the levels of gene expression associated with iron metabolism. When the malignant and normal tissues gene expression levels were analyzed, expression of TFRC increased (1.586-fold); IRP1 (0.594 fold) and miR-122 (0.320 fold) expression decreased; HAMP, FPN1, HFE2, and TMPRSS6 expressions did not change. FPN1 and IRP1 had a positive association, and this association was statistically significant (r = 0.266; p = 0.022). IRP1 and miR-122 had a positive association, and this association had statistical significance (r = 0.231; p = 0.048). Conclusions: Our study portrayed the important association between genes involved in iron hemostasis and breast malignancy. The results could be used to establish new diagnostic techniques in the management of breast malignancies. The alterations in the metabolism of malignant breast cells with normal breast cells could be utilized to achieve advantages in treatment. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.
Self-Induced Nail Disorders: Clinical and Demographical Features
(Wiley, 2025) Dogruel, Gaye Guldiken; Atis, Guldehan; Esen, Mustafa; Demirbas, Gozde Ulutas; Guldogan, Ozge; Demirbas, Abdullah; Goktay, Fatih
BackgroundSelf-induced nail disorders (SINDs) are a subset of body-focused repetitive behaviors (BFRBs) characterized by pathological grooming habits that damage the nail and periungual structures. These disorders were classified into subgroups based on the specific methods individuals use to harm their nails. Despite their prevalence and potential psychological impact, limited data exist. This study aims to investigate the demographic and clinical characteristics of SINDs.MethodsThis multicenter prospective cohort study included 675 patients diagnosed with SINDs at dermatology outpatient clinics between February and June 2024. Data collected included demographic information, SIND subtypes, associated BFRBs, psychiatric history, and family history of BFRBs. Patients were categorized into six SIND subgroups. Approval from the ethical committee was obtained.ResultsThe mean age of SIND onset was 16.60 +/- 10.61 years, with no significant gender difference (p = 0.195). Forty-seven percent of patients belonged to more than one SIND subgroup, and 45.4% had other BFRBs, with cheek/lip biting (55.7%) and acne excori & eacute;e (44.9%) being the most common. Females exhibited higher rates of accompanying BFRBs (54.5% vs. 31.2%; p = 0.001). Patients rarely sought medical treatment (19.1%), even if they felt severe discomfort regarding their habit (56.0%). Patients with diagnosed psychiatric disorders or a family history of BFRBs were more likely to seek treatment (p = 0.001, p = 0.013).ConclusionSINDs often coexist with other BFRBs, predominantly affecting females. While patients are frequently aware of their habits, the rate of seeking medical treatment remains low. Dermatologists play a vital role in identifying SINDs, addressing associated behaviors, and coordinating care for coexisting psychiatric conditions.
Citation - WoS: 1
Psychopathologic Evaluation in Patients with Nasal Bone Fractures
(Sage Publications Inc, 2024) Demir, Songul; Akbudak, M. Mahir; Sizer, Bilal
Background: Nasal bone fractures are pretty common. The most common causes include interpersonal violence, traffic accidents, sports injuries, and falls. This study aimed to assess patients presenting with nasal bone fractures not only for nasal trauma but also for personality disorders, impulsivity, and attention-deficit/hyperactivity disorder (ADHD) using psychiatric questionnaires. Methods: The study included 41 patients, and the control group consisted of 43 volunteers without nasal bone fracture; neither the patients nor the volunteers had previously been diagnosed with or treated for psychiatric disorders. The psychiatric questionnaires administered were the Eysenck Personality Questionnaire Revised-Short Form (EPQR-S), the Barratt Impulsivity Scale-Short Form (BIS-11-SF), and Turgay's Adult ADD/ADHD DSM-IV-based Scale. Results: The most common cause of nasal bone fractures in our study was violence (41.5%), followed by traffic accidents (29.3%), falls (17%), and sports injuries (12.2%). In the EPQR-S assessment, the nasal bone fracture (NBF) group had significantly-higher total scores than the control group (CG) (P < .001). In the subscales of the questionnaire, extroversion, psychoticism, and lie subscale scores were higher in the NBF group than in the CG. In the BIS-11-SF assessment, the NBF group had higher total scores than the CG (P < .001). Assessment using Turgay's adult ADD/ADHD DSM IV-based diagnostic screening and rating scale revealed no statistically-significant difference between the NBF group and the CG in terms of attention deficit and hyperactivity. Conclusion: We found that psychoticism patterns and impulsivity were more prevalent in the patient group, whereas ADD/ADHD was not. The results of our study suggest that performing a psychiatric assessment may be the right decision in patients presenting with NBFs caused by violence, whether they are the aggressor or the victim.
Citation - WoS: 13
Mechanisms of Peptide Hydrolysis by Aspartyl and Metalloproteases
(Royal Society of Chemistry, 2016) Paul, Thomas J.; Barman, Arghya; Ozbil, Mehmet; Bora, Ram Prasad; Zhang, Tingting; Sharma, Gaurav; Prabhakar, Rajeev
Peptide hydrolysis has been involved in a wide range of biological, biotechnological, and industrial applications. In this perspective, the mechanisms of three distinct peptide bond cleaving enzymes, beta secretase (BACE1), insulin degrading enzyme (IDE), and bovine lens leucine aminopeptidase (BILAP), have been discussed. BACE1 is a catalytic Asp dyad [Asp, Asp(-)] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively. Specifically, enzyme-substrate interactions and the roles of metal ion(s), the ligand environment, second coordination shell residues, and the protein environment in the functioning of these enzymes have been elucidated. This information will be useful to design small inhibitors, activators, and synthetic analogues of these enzymes for biomedical, biotechnological, and industrial applications.
P323L Mutation in a Case with Prolonged SARS-CoV-2 PCR Positivity
(Ankara Microbiology Soc, 2023) Yucebag, Ebru; Arslan, Nese; Tok, Yesim; Nohut, Okan Kadir; Yilmaz, Seda Salman; Kuskucu, Mert Ahmet; Midilli, Kenan
Coronavirus disease-2019 (COVID-19) emerged in the last months of 2019 and caused a pandemic effecting the whole world. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 has changed by various mutations since the day it was first identified, causing the pandemic to continue. Age, male gender, obesity, and comorbidity, which are general risk factors for COVID-19, can also cause prolonged PCR positivity. In this report, a case of 37-year-old male who is working in the hospital's COVID-19 molecular diagnostics laboratory was presented. He was vaccinated with three doses of inactivated vaccine, CoronaVac (Sinovac Biotech, Beijing-China), within the context of the vaccination program carried out in Turkiye. His first SARS-CoV-2 positivity was detected on 12.01.2021, four months after the last vaccination, and he continued to be detected positive for SARS-CoV-2 throughout a period of 39 days by quantitative reverse transcription polymerase chain reaction (qRT-PCR) tests performed with 2-3-day intervals. The patient has a 20-pack/year smoking history and his body mass index (BMI) was 29.8 kg/m(2) at the time of his COVID-19. The case, which was clinically defined as mild COVID-19 with symptoms including back and headache, cough, fever (38.5 degrees C), and loss of taste-smell, and without any additional complications or respiratory distress during the disease process. In the radiological examination, the lung was found within normal ranges. Prophylactic enoxaparin sodium anti-xa IU/0.6 ml was administered to the patient due to his cardiovascular risk, and no additional treatment was given. Whole genome sequencing was performed from nasopharyngeal swab samples of the patient at the beginning and 16th day of the infection to investigate the the specific genomic features and mutation pattern of the virus in the host over time, due to the prolonged SARS-CoV-2 PCR positivity. Library preparation for the whole next-generation sequencing (NGS) was performed by the SARS-CoV-2 Panel, Paragon CleanPlex kit (Paragon Genomics, USA), and indexing of the library was done by Clean-Plex Dual-Indexed PCR Primers for Illumina Set B kit (Paragon Genomics, USA). NGS analysis was performed on the Illumina Miniseq (Illumina, USA) platform. As a result of the bioinformatics evaluation, both samples were determined as SARS-CoV-2 Delta variant (Nextclade; 21J-Delta variant, Pango lineage; AY.43). Remarkably, the SARS-CoV-2 sequences in the two samples taken 15 days apart; several identical mutations; such as D614G in the S gene, P323L in the ORF 1b gene region, and P1228L in the Nsp3 gene region, were detected. Besides that, when compared to the first sample, three additional mutations (P383L, P539S, L838I) were observed in the sequence of the second sample, which led to three amino acid changes, the clinical significance of which has not yet been determined in the literature. It is thought that; these mutations that change amino acid expression, as well as the other three mutations detected, may contribute to the improvement of the fitness of the virus and may be one of the factors responsible for the prolonged SARS-CoV-2 PCR positivity. Additional data to be obtained by further epidemiological sequencing studies will shed light on this issue.
Similar Clinical and Dermoscopic Features of Cutaneous Schwannomas
(Mattioli 1885, 2024) Dogruel, Gaye Guldiken; Atis, Guldehan; Gunes, Pembegul
Citation - WoS: 1
Citation - Scopus: 1
Technostress among Nurses: Boon or Bane? The Moderated Mediation Model
(BMC, 2025) Kopuz, Koray; Turgut, Meryem; Aydin, Gamze
Background Today, increasing digitalization and intensified human-computer interaction in healthcare services have significantly changed nurses' daily work processes. This situation has caused the emergence of a type of stress called technostress among nurses. The negative outcomes of technostress, generally referred to as its dark side, have been frequently emphasized in the literature. On the other hand, studies on the bright side of technostress, that is, its positive outcomes, are quite limited. Based on the job demands-resources model, this study assumes that technostress creators may have negative and positive outcomes.
Aim In this context, this study aims to examine the indirect effects of technostress creators on job satisfaction through techno-eustress, on burnout through techno-distress, and how these indirect effects change depending on technical support and technology competence.
Methods This study adopted a quantitative, correlational design and was conducted using a cross-sectional survey. Data were collected at a single time point from a convenience sample of nurses working in one hospital. The proposed research model was empirically tested using path analysis.
Results Findings show that technostress creators increase burnout through techno-distress and job satisfaction through techno-eustress. It also shows that these indirect effects vary depending on the technology competence levels of nurses, and as the technology competence level increases, the indirect effects weaken.
Conclusion In conclusion, the research findings revealed that, unlike other studies in the literature, technostress creators cannot be described as just a boon or a bane but can produce positive or negative outcomes through various mechanisms.
Successful Treatment of Penile Venous Malformation with a 577-nm Laser
(Lippincott Williams & Wilkins, 2024) Kazan, Didem; Bayramguerler, Dilek
TLR2 Variants and Helicobacter pylori: Revisiting a Controversial Link
(2025) Kırkık, D.; Demircioğlu, S.; Tas, S.K.
Objective: Although polymorphisms in the Toll-like receptor 2 (TLR2) gene have been proposed as host genetic factors influencing susceptibility to Helicobacter pylori infection, existing data remain inconclusive. This meta-analysis aimed to clarify whether two common variants - rs3804099 and del -196 to -174 - contribute to infection risk across diverse populations. Materials and methods: A systematic search of PubMed, Scopus, and Web of Science (up to January 2025) identified eligible case-control studies examining the association between TLR2 polymorphisms and H. pylori infection. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models. Heterogeneity, publication bias, and sensitivity were assessed according to PRISMA 2020 guidelines. Results: Ten studies comprising 4,521 subjects were included. Pooled analyses under allelic, dominant, recessive, homozygous, and heterozygous models revealed no significant association between either rs3804099 or del -196 to -174 polymorphisms and infection risk. Substantial inter-study heterogeneity was observed, particularly for rs3804099, but sensitivity analyses confirmed the stability of pooled results. Conclusion: This meta-analysis refutes a consistent genetic association between TLR2 rs3804099 or del -196 to -174 polymorphisms and H. pylori infection. The findings suggest that host innate immunity variability alone does not explain differences in infection susceptibility among populations. Future studies integrating bacterial virulence genotypes and host immunogenetic profiles are warranted to delineate population-specific risk mechanisms. © 2025 The Author(s).
Citation - WoS: 1
Opinions of Female Academicians on Oocyte Freezing: A Qualitative Study
(Assoc Medica Brasileira, 2023) Tandogan, Oezden; Kugcumen, Gozde; Satilmi, Ilkay Guengoer
OBJECTIVE: The aim of this study was to evaluate the opinions of female academicians about oocyte freezing.METHODS: This qualitative study included 12 single academic women who had not yet entered menopause, did not have children, and were continuing their doctoral education in Istanbul, Turkey, between August and September 2022. Data were collected with semi-structured interviews and evaluated by content analysis.RESULTS: Three main themes were "Difficulty of fertility in academics," "Advantages of oocyte freezing," and "Concerns about oocyte freezing." Participants mostly had positive attitudes about the advantages of oocyte cryopreservation, but they had concerns about pregnancies obtained with frozen oocytes.CONCLUSION: The academic women attributed fertility as an obstacle to their career and experienced anxiety about fertility. They were aware of the advantages of oocyte cryopreservation; however, they defined the pregnancy with oocyte freezing as artificial.

Browse

Recent Submissions