PubMed İndeksli Yayınlar Koleksiyonu

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Citation - WoS: 16
Citation - Scopus: 21
3D Printed Styrax Liquidus (Liquidambar orientalis Miller)-Loaded Poly (L-Lactic Acid)/Chitosan Based Wound Dressing Material: Fabrication, Characterization, and Biocompatibility Results
(Elsevier B.V., 2023) Cakmak, Hanife Yuksel; Ege, Hasan; Yilmaz, Senanur; Agturk, Gokhan; Yontem, Fulya Dal; Enguven, Gozde; Sarmis, Abdurrahman; Cakmak, Zeren; Gunduz, Oguzhan; Ege, Zeynep Ruya
The medicinal plant of Styrax liquidus (ST) (sweet gum balsam) which extracted from Liquidambar orientalis Mill tree, was loaded into the 3D printed polylactic acid (PLA)/chitosan (CS) based 3D printed scaffolds to investigate its wound healing and closure effect, in this study. The morphological and chemical properties of the ST loaded 3D printed scaffolds with different concentrations (1 %, 2 %, and 3 % wt) were investigated by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR), respectively. In addition, the mechanical and thermal properties of the materials were investigated by Tensile test and Differential Scanning Calorimetry (DSC), respectively. The antimicrobial activities of the ST loaded 3D printed scaffolds and their incubation media in the PBS (pH 7.4, at 37 °C for 24 h) were investigated on two Gram-positive and two Gram-negative standard pathogenic bacteria with the agar disc diffusion method. The colorimetric MTT assay was used to determine the cell viability of human fibroblast cells (CCD-1072Sk) incubated with free ST, ST loaded, and unloaded 3D printed scaffolds. The 1 % and 2 % (wt) ST loaded PLA/CS/ST 3D printed scaffolds showed an increase in the cell number. Annexin V/PI double stain assay was performed to test whether early or late apoptosis was induced in the PLA/CS/1 % ST and PLA/CS/2 % ST loaded groups and the results were consistent with the MTT assay. Furthermore, a wound healing assay was carried out to investigate the effect of ST loaded 3D printed scaffolds on wound healing in CCD-1072Sk cells. The highest wound closure compared to the control group was observed on cells treated with PLA/CS/1 % ST for 72 h. According to the results, novel biocompatible ST loaded 3D printed scaffolds with antimicrobial effect can be used as wound healing material for potential tissue engineering applications. © 2023 Elsevier B.V.
Citation - WoS: 13
Citation - Scopus: 12
A CAD of Fully Automated Colonic Polyp Detection for Contrasted and Non-Contrasted CT Scans
(Springer Heidelberg, 2017) Tulum, Gökalp; Bolat, Bülent; Osman, Onur; Tulum, Gokalp; Bolat, Bulent; Osman, Onur
Computer-aided detection (CAD) systems are developed to help radiologists detect colonic polyps over CT scans. It is possible to reduce the detection time and increase the detection accuracy rates by using CAD systems. In this paper, we aimed to develop a fully integrated CAD system for automated detection of polyps that yields a high polyp detection rate with a reasonable number of false positives. The proposed CAD system is a multistage implementation whose main components are: automatic colon segmentation, candidate detection, feature extraction and classification. The first element of the algorithm includes a discrete segmentation for both air and fluid regions. Colon-air regions were determined based on adaptive thresholding, and the volume/length measure was used to detect air regions. To extract the colon-fluid regions, a rule-based connectivity test was used to detect the regions belong to the colon. Potential polyp candidates were detected based on the 3D Laplacian of Gaussian filter. The geometrical features were used to reduce false-positive detections. A 2D projection image was generated to extract discriminative features as the inputs of an artificial neural network classifier. Our CAD system performs at 100% sensitivity for polyps larger than 9 mm, 95.83% sensitivity for polyps 6-10 mm and 85.71% sensitivity for polyps smaller than 6 mm with 5.3 false positives per dataset. Also, clinically relevant polyps (6 mm) were identified with 96.67% sensitivity at 1.12 FP/dataset. To the best of our knowledge, the novel polyp candidate detection system which determines polyp candidates with LoG filters is one of the main contributions. We also propose a new 2D projection image calculation scheme to determine the distinctive features. We believe that our CAD system is highly effective for assisting radiologist interpreting CT.
Citation - WoS: 14
Citation - Scopus: 14
A Cross-Cultural Investigation Into the Relationships Among Parental Support for Basic Psychological Needs, Sense of Uniqueness and Happiness
(Routledge Journals, Taylor & Francis Ltd, 2014) Şimşek, Ömer Faruk; Demir, Melikşah; Simsek, Omer Faruk; Demir, Meliksah
A significant number of empirical studies have reported that parental support for basic psychological needs is a robust correlate of adolescent happiness. Yet, less is known about the mechanisms responsible for this link. The present study proposed a model suggesting that personal sense of uniqueness explains why satisfaction of basic psychological needs in parent-child relationships is related to happiness. This mediational model was tested among late adolescents in Turkey and the United States. Analyses relying on structural equation modeling and bootstrapping supported the model in both cultures. Implications of the findings for theory and cross-cultural research are discussed. Directions for future research that could improve our understanding of the dynamic interplay between basic needs, sense of uniqueness and well-being are provided.
Citation - WoS: 3
Citation - Scopus: 4
A Neural Marker of the Start-Gun in Interval Timing: Onset N1P2
(American Psychological Association, 2019) Düzcü, Halil; Duzcu, Halil
Although the neural markers of interval timing have been widely studied, the events that determine the onset and offset of an interval have only recently started to gain attention. In the present study, I compare the predictions of the perceptual (preonset and start-gun) and decisional bias hypotheses with respect to onset N1P2 amplitude, the point of subjective equality (PSE) and delta/theta activity. The onsets of the comparison intervals (CIs) were manipulated to begin earlier, later, or on-time with regard to a standard interval (SI). Results supported the start-gun account by demonstrating an increase in the N1P2 amplitude and delta power in the "early" and "late" onset conditions due to temporal mismatch. Delayed or premature initiation of timing with respect to the predicted temporal point were associated with rightward and leftward shifts in the PSEs of the "early" and "late" onset conditions, respectively. In addition to the observed increase in temporal prediction-related delta activity in the "early" and "late" onset conditions, higher theta power in the "early" onset suggested an additional neural response for unexpected events that might be linked to response caution. Moreover, the ramping activity during the CIs, namely the contingent negative variation (CNV), showed a decision-related attenuation toward the end of an interval in the "late" onset. The latter finding was supported by the changes in offset N1P2 amplitude. The present study contributes to the interval-timing literature by presenting support in favor of the hypothesis that the onset N1P2 is a neural marker for the initiation of timing.
Citation - WoS: 10
A Novel Frameshift Mutation of Malonyl-CoA Decarboxylase Deficiency: Clinical Signs and Therapy Response of a Late-Diagnosed Case
(Wiley, 2017) Ersoy, Melike; Akyol, Mehmet Bedir; Ceylaner, Serdar; Biçer Çakır, Nihan; Ersoy, Melike; Akyol, Mehmet Bedir; Ceylaner, Serdar; Bicer, Nihan Cakir
Key Clinical Message We evaluate the clinical findings and the treatment response of a late-diagnosed case with a novel homozygous insertion c.13_14insG (p.P6Afs*202) result in a frameshift mutation in MLYCD gene. Both cardiac and neurologic involvements were mild when compared to previously reported cases, and see low-fat/high-carbohydrate diet treatment is highly effective.
Citation - WoS: 19
Citation - Scopus: 21
A Novel Technique for the Reduction of Pesticide Residues by a Combination of Low-Intensity Electrical Current and Ultrasound Applications: A Study on Lettuce Samples
(Elsevier Science Ltd, 2021) Cengiz, Mehmet Fatih; Basancelebi, Onur; Baslar, Mehmet; Certel, Muharrem; Cengiz, Mehmet Fatih; Basancelebi, Onur; Baslar, Mehmet; Certel, Muharrem
In this study, effects of low-intensity electrical currents (200, 800 and 1400 mA), ultrasound frequencies (24 and 40 kHz) and their combinations were applied at the duration period of 2, 4, 6, 8, and 10 min for the degradation of captan, thiamethoxam and metalaxyl residues in lettuce samples. Residues of the pesticides were determined by gas chromatography with tandem mass spectrometry and electron capture detector. The results indicated that the combination of low-intensity electrical current and ultrasound was found to be effective for the reduction of the pesticides. The most effective combination was obtained to be current of 1400 mA and ultrasound frequency of 24 kHz at 10 min. Under this circumstance, 92.57, 81.99 and 93.09% of captan, thiamethoxam and metalaxyl residues were decreased, respectively. The findings suggest that the combination of low-intensity electrical current and ultrasound applications has an important potential for the degradation of pesticide residues.
Citation - WoS: 1
Citation - Scopus: 2
A Patient with Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery (ALCAPA Syndrome) and 13 Live Births
(Clinics Cardive Publishing Pty Ltd, 2019) Yolcu, Mustafa; Bilal, Mehmet Salih; Avşar, Mustafa Kemal; Yıldırım, Özgür; Yolcu, Mustafa; Bilal, Mehmet Salih; Avsar, Mustafa Kemal; Yildirim, Ozgur
Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) or Bland-White-Garland syndrome is a rarely seen congenital anomaly. Adult and infantile types arc defined according to the degree of collateral development between the left coronary artery (LCA) and right coronary artery (RCA). If left untreated. ALCAPA has a 90% mortality rate in the first year of life. primarily due to myocardial ischaemia and heart failure. The degree of collateral development and the related LCA perfusion in ALCAPA syndrome determine the occurence of symptoms. Herein, we present a case of a female patient who had previously, without any symptoms, given live birth to 13 babies. She had been experiencing exertional angina, which started long after the delivery of her 13th child. Since our patient had well-developed collaterals to the LCA, she was asymptomatic and able to give birth to the children via the vaginal route without any problems. Having well-formed collateral vessels between the RCA and LCA may prevent patients from developing symptoms, and even stressful conditions such as pregnancy may be tolerable.
Citation - WoS: 18
Citation - Scopus: 18
A Review of Functional Characterization of Single Amino Acid Change Mutations in HNF Transcription Factors in MODY Pathogenesis
(Springer, 2021) Çubuk, Hasan; Yalçın Çapan, Özlem; Cubuk, Hasan; Yalcin Capan, Ozlem
Mutations in HNF transcription factor genes cause the most common subtypes of maturity-onset of diabetes of youth (MODY), a monogenic form of diabetes mellitus. Mutations in the HNF1-alpha, HNF4-alpha, and HNF1-beta genes are primarily considered as the cause of MODY3, MODY1, and MODY5 subtypes, respectively. Although patients with different subtypes display similar symptoms, they may develop distinct diabetes-related complications and require different treatments depending on the type of the mutation. Genetic analysis of MODY patients revealed more than 400 missense/nonsense mutations in HNF1-alpha, HNF4-alpha, and HNF1-beta genes, however only a small portion of them are functionally characterized. Evaluation of nonsense mutations are more direct as they lead to premature stop codons and mostly in mRNA decay or nonfunctional truncated proteins. However, interpretation of the single amino acid change (missense) mutation is not such definite, as effect of the variant may vary depending on the location and also the substituted amino acid. Mutations with benign effect on the protein function may not be the pathologic variant and further genetic testing may be required. Here, we discuss the functional characterization analysis of single amino acid change mutations identified in HNF1-alpha, HNF4-alpha, and HNF1-beta genes and evaluate their roles in MODY pathogenesis. This review will contribute to comprehend HNF nuclear family-related molecular mechanisms and to develop more accurate diagnosis and treatment based on correct evaluation of pathologic effects of the variants.
Citation - WoS: 62
Citation - Scopus: 69
A Roadside Study of Observable Driver Distractions
(Taylor & Francis Inc, 2015) Sullman, Mark J. M.; Prat, Francesc; Taşçı Kuzu, Duygu; Sullman, Mark J. M.; Prat, Francesc; Tasci, Duygu Kuzu
Objective: This study investigated the prevalence of observable distractions while driving and the effect of drivers' characteristics and time-related variables on their prevalence. Methods: Using roadside observation, 2 independent observers collected data at 4 randomly selected locations in St. Albans, UK. Results: Of the 10,984 drivers observed, 16.8% were engaged in a secondary task, with talking to passengers being the most common distraction (8.8%), followed by smoking (1.9%) and talking on a hands-free mobile phone (1.7%). An additional 1.0% were observed talking on a handheld phone, and the rest of the distractions (e.g., texting, drinking) were recorded in less than 1% of the drivers observed. Gender-related differences were found for a number of different distractions (i.e., talking to passengers, drinking, and handheld mobile phone conversations), but age emerged as a significant predictor for most secondary tasks, including talking to passengers, smoking, hands-free mobile phone use, handheld mobile phone use, texting/keying numbers, drinking, and engagement in any type of distraction (all distractions combined). The overall pattern for age was that middle-aged and older drivers were less likely to be distracted than younger drivers. Conclusions: This work provides further evidence of the relatively high rate of distracted driving in the UK. The findings clearly indicate that younger drivers are more likely to drive distracted, which probably contributes to their higher crash rates.
Citation - WoS: 2
Citation - Scopus: 3
A Volumetric Study of the Corpus Callosum in the Turkish Population
(Thieme Medical Publishing Inc, 2021) Acer, Niyazi; Soysal, Handan; Özdemir, Meltem; Eraslan, Önder; Soysal, Handan; Acer, Niyazi; Ozdemir, Meltem; Eraslan, Onder
Objective The aim of this study is to measure the average corpus callosum (CC) volume of healthy Turkish humans and to analyze the effects of gender and age on volumes, including the genu, truncus, and splenium parts of the CC. Patients and Methods Magnetic resonance imaging brain scans were obtained from 301 healthy male and female subjects, aged 11 to 84 years. The median age was 42 years (min-max: 11-82) in females and 49 years (min-max: 12-84) in males. Corpus callosum and its parts were calculated by using MRICloud. CC volumes of each subject were compared with those of the age and gender groups. Results All volumes of the CC were significantly higher in males than females. All left volumes except BCC were significantly higher than the right volumes in both males and females. The oldest two age groups (50-69 and 70-84 years) were found to have higher bilateral CC volumes, and bilateral BCC volumes were also higher than in the other two age groups (11-29 and 30-49 years). Conclusion The results suggest that compared with females/males, females have a faster decline in the volume of all volumes of the CC. We think that quantitative structural magnetic resonance data of the brain is vital in understanding human brain function and development.
Citation - WoS: 2
Citation - Scopus: 3
Aberrant miR-3135b and miR-1273g-3p Expression in the Peripheral Blood Samples of BRCA1/2 (±) Ovarian Cancer Patients
(Elsevier Ltd, 2024) Tuncer, Seref Bugra); Celik, Betul; Erciyas, Seda Kilic; Erdogan, Ozge Sukruoglu; Pasin, Ozge; Avsar, Mukaddes; Gultaslar, Busra Kurt; Ghafour, Arash Adamnejad; Uyaroglu, Gamze; Odemis, Demet Akdeniz; Yazici, Hulya
Ovarian cancer (OC) ranks as the eighth most prevalent malignancy among women globally. The short non-coding RNA molecules, microRNAs (miRNAs) target multiple mRNAs and regulate the gene expression. Here in this study, we aimed to validate miR-3135b and miR-1273g-3p as novel biomarkers for prognostic and diagnostic factor OC. After RNA isolation, we analyzed the miR-3135b and miR-1273g-3p expression in peripheral blood samples derived from 150 OC patients. Subsequently, we compared their expression levels with 100 healthy controls. The differences of miR-3135b and miR-1273g-3p expression were detected using the Quantitative Real Time-PCR (qRT-PCR) technique following miRNA-specific cDNA synthesis pursing miRNA separation. The miR-3135b and miR-1273g-3p were higher in OC patients who tested positive for BRCA1/2 compared to BRCA-negative patients, and healthy cases. The level of miR-3135b demonstrated a roughly 4.82-fold increase in OC patients in comparison to the healthy cases, while miR-1273g-3p expression exhibited a roughly 6.77-fold increase. The receiver operating characteristic (ROC) analysis has demonstrated the potential of miR-3135b and miR-1273g-3p as markers for distinguishing between OC patients and healthy controls. The higher expressions of miR-3135b and miR-1273g-3p could be associated with OC development. Moreover, miR-3135b may have a diagnostic potential and miR-1273g-3p may have both diagnostic and prognostic potential in OC cell differentiation. The string analysis has revealed an association between miR-1273g-3p and the MDM2 gene, suggesting a potential link to tumor formation through the proteasomal degradation of the TP53 tumor suppressor gene. Additionally, the analysis indicates an association of miR-1273g-3p with CHEK1, a gene involved in checkpoint-mediated cell cycle arrest. String analysis also indicates that miR-3135b is associated with the MAPK1 gene, causing activation of the oncogenesis cascade. In conclusion, miR-1273g-3p, and miR-3135b exhibit significant potential as diagnostic markers. However, further research is needed to comprehensively investigate these miRNAs diagnostic and predictive characteristics in a larger cohort. © 2023 The Authors
Citation - WoS: 1
Citation - Scopus: 1
Acceptance Rates and Reasons for Social Oocyte Cryopreservation Among Women: Systematic Review and Meta-Analysis
(Springer/Plenum Publishers, 2025) Tandogan, Ozden; Kugcumen, Gozde; Satilmis, Ilkay Gungor
The aim of this systematic review and meta-analysis was to determine the acceptance rates and reasons for social oocyte cryopreservation (SOC) in the general population (subgroup 1) and healthcare professionals/students (subgroup 2) according to the current literature. Relevant studies published between 2007 and Sept 2023 were identified from electronic databases, including PubMed, EBSCO MEDLINE Complete, Web of Science, Science Direct, Scopus, and CINAHL. Quantitative studies reporting women's acceptance rates and reasons for social oocyte cryopreservation were eligible. A total of 20 quantitative studies were included in this process. Meta-analyses were conducted using random-effects models to evaluate study effect sizes. A total of 20 articles were analyzed. While the acceptance rate of SOC women in the general population was 56.5% (95% CI = 47.8-64.9%; tau(2) = 0.98, df = 20; p < 0.001), this rate was between 42 and 66% in female healthcare professionals/students (p > 0.05; I-2 = 98.46%; df = 20; p < 0.001). Among the acceptable reasons for SOC, cost-recovery (67.9%, 95% CI = 58-76%, I-2 = 97.88%, tau(2) = 0.95, df = 6; p < 0.001) and inability to find a suitable partner (45.7%, 95% CI = 32.6-59.5%; I-2 = 97.96%, df = 10; p < 0.001) stand out. Acceptance rates did not differ significantly between the general population and healthcare professionals/students' inability to find a suitable partner (p > 0.05). The meta-analysis shows that more than half of women accept SOC, with the acceptance rate increasing in the absence of a partner and if the cost is affordable.
Citation - WoS: 2
Citation - Scopus: 4
Activity of CDK4/6 Inhibitors and Parameters Affecting Survival in Elderly Patients in Age-Subgroups: Turkish Oncology Group (TOG) Retrospective Study
(BMC, 2024) Kahraman, Seda; Hizal, Mutlu; Demirel, Burcin Cakan; Guven, Deniz Can; Gumusay, Ozge; Uluc, Basak Oyan; Sendur, Mehmet Ali Nahit
Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart of care for first- and second-line therapies in combination with endocrine therapy (ET) for HR+/HER2- metastatic breast cancer (MBC) patients. It has been reported that combination therapy is more effective than ET alone and is safe in elderly patients as well as young patients. Nevertheless, elderly and very old patients with HR+/HER2-MBC treated with CDK4/6 inhibitor (CDK4/6i) combinations are relatively underrepresented in randomized controlled trials. To contribute to the literature, we investigated the real-world efficacy, factors associated with survival and the rates of adverse events (AEs) of the treatment with palbociclib or ribociclib plus ET in the HR+/HER2- MBC patient cohort over the age of 65 for age subgroups. In this retrospective study, 348 patients were divided into subgroups: 65-69 years old, 70-79 years old and 80 years and older. Median PFS (mPFS) for whole group was 18.3 (95% CI,14.3-22.3) months. There was no significant difference in mPFS between age groups (p = 0.75). The estimated median OS (mOS) was 39.5 (95% CI, 24.9-54.1) months and there was no significant difference between age groups (p = 0.15). There was a meaningfull numerical difference that did not reach statistical significance in patients who received CDK4/6i treatment as the first line for MBC. Grade 3-4 AEs were reported in 42.7% for the entire group, and neutropenia was the most common (37.3%). It can be concluded that combination therapy with palbociclib or ribociclib with an ET partner has similar efficacy and is safe among subgroups of older patients diagnosed with HR+/HER2-MBC.
Citation - WoS: 1
Acute Sleep Deprivation: Impairment of Biventricular Function Assesed By Speckle Tracking Echocardiography in Healthy Subjects
(Springer Heidelberg, 2023) Bingol, Gulsum; Demir, Fulya Avci; Ozmen, Emre; Unlu, Serkan; Ozden, Ozge; Boyuk, Ferit; Tuner, Hasim; Nasifov, Muharrem; Camkiran, Volkan; Sari, Ibrahim
ObjectivesSleep deprivation (SD) has been found to be associated with an increased incidence of adverse cardiovascular disease (CVD) events. The aim of this study was to investigate whether or not acute SD has a pathological effect on the geometry and the systolic and diastolic functions of the right and left heart chambers by standard transthoracic echocardiography (TTE) and speckle tracking echocardiography (STE) in healthy individuals with acute SD.MethodsNurses with no history of acute or chronic diseases underwent TTE and STE after working a night shift, a sleepless period of 24 h and 7 days of normal sleep after the night shift. Measurements of TTE and STE taken in the rested state were compared with those taken after 24 h of sleep deprivation.ResultsThe study included 52 nurses (38 women, 73%). The mean age of the study population was 27.9 +/- 7.4 years and mean BMI was 24.1 +/- 4.8. Left atrial reservoir (51.5 +/- 13.5 vs. 45.4 +/- 10; p = 0.004), conduit (- 37.3 +/- 11.3 vs. - 33.6 +/- 7.9; p = 0.01), left ventricular global longitudinal strain (LVGLS, - 22.6 +/- 2.4 vs. - 21.3 +/- 2.4; p = 0.001), right ventricular global longitudinal strain (RVGLS, - 25.3 +/- 3.7 vs. - 23.5 +/- 3.9; p = 0.005) and right ventricular free wall longitudinal strain (RVFWSL, - 29.1 +/- 4.2 vs. - 27 +/- 4.5; p = 0.001) were impaired significantly after SD.ConclusionThis study is the first to investigate the negative effects of acute sleep deprivation on LV and RV strain in healthy adults using echocardiography. The findings showed that acute sleep deprivation leads to deterioration in function of both ventricles and left atrium. Speckle tracking echocardiography demonstrated subclinical diminished heart function.
Citation - Scopus: 2
Acute Sleep Deprivation: Impairment of Biventricular Function Assessed by Speckle Tracking Echocardiography in Healthy Subjects
(Springer Science and Business Media Deutschland GmbH, 2023) Bingöl, G.; Avcı Demir, F.A.; Ozmen, E.; Ünlü, S.; Özden, Ö.; Böyük, F.; Sarí, I.
Objectives: Sleep deprivation (SD) has been found to be associated with an increased incidence of adverse cardiovascular disease (CVD) events. The aim of this study was to investigate whether or not acute SD has a pathological effect on the geometry and the systolic and diastolic functions of the right and left heart chambers by standard transthoracic echocardiography (TTE) and speckle tracking echocardiography (STE) in healthy individuals with acute SD. Methods: Nurses with no history of acute or chronic diseases underwent TTE and STE after working a night shift, a sleepless period of 24 h and 7 days of normal sleep after the night shift. Measurements of TTE and STE taken in the rested state were compared with those taken after 24 h of sleep deprivation. Results: The study included 52 nurses (38 women, 73%). The mean age of the study population was 27.9 ± 7.4 years and mean BMI was 24.1 ± 4.8. Left atrial reservoir (51.5 ± 13.5 vs. 45.4 ± 10; p = 0.004), conduit (− 37.3 ± 11.3 vs. − 33.6 ± 7.9; p = 0.01), left ventricular global longitudinal strain (LVGLS, − 22.6 ± 2.4 vs. − 21.3 ± 2.4; p = 0.001), right ventricular global longitudinal strain (RVGLS, − 25.3 ± 3.7 vs. − 23.5 ± 3.9; p = 0.005) and right ventricular free wall longitudinal strain (RVFWSL, − 29.1 ± 4.2 vs. − 27 ± 4.5; p = 0.001) were impaired significantly after SD. Conclusion: This study is the first to investigate the negative effects of acute sleep deprivation on LV and RV strain in healthy adults using echocardiography. The findings showed that acute sleep deprivation leads to deterioration in function of both ventricles and left atrium. Speckle tracking echocardiography demonstrated subclinical diminished heart function. © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Citation - WoS: 1
Citation - Scopus: 2
Adaptation and Psychometric Assessment of the Turkish Version of the Perceived Access to Health Care Questionnaire: Validity and Reliability Analysis
(MDPI, 2025) Yilmaz, Salim; Ates, Metin; Abay, Perihan
Background/Objectives: Access to health services is a fundamental element of social welfare and individual quality of life. This study aimed to fill gaps in the Turkish literature regarding the assessment and perception of access to health services and to introduce a valid and reliable measurement tool for this purpose. Methods: This methodological cross-sectional study was conducted in Istanbul with 639 adults aged 18-65 years. Linguistic and cultural appropriateness were evaluated, and validation was assessed through known group validity using sociodemographic factors. Convergent and divergent validity analyses were performed. Reliability was examined using alpha coefficients and 27% percentile discrimination. A secondary confirmatory factor analysis provided the overall score for the scale. Results: The scale was validated on four factors, and seven items were removed during refinement, resulting in a final twenty-three-item scale. Internal consistency was robust, with alpha coefficients of 0.899 for acceptability and affordability, 0.825 for availability, 0.773 for accommodation, 0.892 for awareness, and 0.943 for overall access. Perceived access to health services was significantly correlated with age, beliefs in easy access to health, and satisfaction with outpatient care. Conclusions: The validated scale provides a reliable tool for measuring perceptions of access to health services, which is essential for shaping health policies and practices. Comprehensive assessments using such tools can help discern nuanced distinctions between perceived and actual access.
Citation - WoS: 9
Citation - Scopus: 9
Advanced Bioresin Formulation for 3D-Printed Bone Scaffolds
(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Sakarya, Deniz; Zorlu, Tolga; Yucel, Sevil; Sahin, Yesim Muge; Ozarslan, Ali Can
In bone tissue engineering, scaffold attributes such as pore dimensions and mechanical strength are crucial. This study synthesized polycaprolactone dimethacrylate (PCLDMA) from polycaprolactone (PCL), incorporating epichlorohydrin (Epi-PCL) and methacryloyl chloride (Meth-Cl). PCLDMA was blended with polylactic acid (p-PLA) to 3D-print bone scaffolds using stereolithography (SLA). Analytical techniques included nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and compression testing. Degradation kinetics and cell viability were investigated using human osteoblast (HOB) cells. Findings revealed PCLDMA/p-PLA composite scaffold superiority over the original polymers. Notably, PCLDMA-60 (60% PCLDMA, 40% p-PLA) displayed optimal properties. Compressive strength varied from 0.019 to 16.185 MPa, porosity from 2% to 50%, and degradation rates from 0% to 0.4% over three days. Cell viability assays affirmed biocompatibility across various PCLDMA ratios. In conclusion, PCLDMA/p-PLA composite scaffolds, particularly PCLDMA-60, show great potential in bone tissue engineering. © 2024 by the authors.
Advancing Patient Care with AI: A Unified Framework for Medical Image Segmentation Using Transfer Learning and Hybrid Feature Extraction
(Frontiers Media SA, 2025) Cevik, Nazife; Cevik, Taner; Osman, Onur; Alsubai, Shtwai; Rasheed, Jawad
Background Accurate medical image segmentation significantly impacts patient outcomes, especially in diseases such as skin cancer, intestinal polyps, and brain tumors. While deep learning methods have shown promise, their performance often varies across datasets and modalities. Combining advanced segmentation techniques with traditional feature extraction approaches may enhance robustness and generalizability.Objective This study aims to develop an integrated framework combining segmentation, advanced feature extraction, and transfer learning to enhance segmentation accuracy across diverse medical imaging (MI) datasets, thus improving classification accuracy and generalization capabilities.Methods We employed independently trained U-Net models to segment skin cancer, polyps, and brain tumor regions from three separate MI datasets (HAM10000, Kvasir-SEG, and Figshare Brain Tumor dataset). Moreover, the study applied classical texture-based feature extraction methods, namely Local Binary Patterns (LBP) and Gray-Level Co-occurrence Matrix (GLCM), processing each Red Green Blue (RGB) channel separately using an offset [0 1] and recombining them to create comprehensive texture descriptors. These segmented images and extracted features were subsequently fine-tuned pre-trained transfer learning models. We also assessed the combined performance on an integrated dataset comprising all three modalities. Classification was performed using Support Vector Machines (SVM), and results were evaluated based on accuracy, recall (sensitivity), specificity, and the F-measure, alongside bias-variance analysis for model generalization capability.Results U-Net segmentation achieved high accuracy across datasets, with particularly notable results for polyps (98.00%) and brain tumors (99.66%). LBP consistently showed superior performance, especially in skin cancer and polyp datasets, achieving up to 98.80% accuracy. Transfer learning improved segmentation accuracy and generalizability, particularly evident in skin cancer (85.39%) and brain tumor (99.13%) datasets. When datasets were combined, the proposed methods achieved high generalization capability, with the U-Net model achieving 95.20% accuracy. After segmenting the lesion regions using U-Net, LBP features were extracted and classified using an SVM model, achieving 99.22% classification accuracy on the combined dataset (skin, polyp, and brain).Conclusion Integrating deep learning-based segmentation (U-Net), classical feature extraction techniques (GLCM and LBP), and transfer learning significantly enhanced the accuracy and generalization capabilities across multiple MI datasets. The methodology provides robust, versatile framework applicable to various MI tasks, supporting advancements in diagnostic precision and clinical decision-making.
Citation - WoS: 6
Agglomerated Serum Albumin Adsorbed Protocatechuic Acid Coated Superparamagnetic Iron Oxide Nanoparticles as a Theranostic Agent
(Institute of Physics, 2023) Bozoğlu, S.; Arvas, M.B.; Varlı, H.S.; Uçar, B.; Acar, T.; Karatepe, N.
Iron oxide nanoparticles have been one of the most widely used nanomaterials in biomedical applications. However, the incomplete understanding of the toxicity mechanisms limits their use in diagnosis and treatment processes. Many parameters are associated with their toxicity such as size, surface modification, solubility, concentration and immunogenicity. Further research needs to be done to address toxicity-related concerns and to increase its effectiveness in various applications. Herein, colloidally stable nanoparticles were prepared by coating magnetic iron oxide nanoparticles (MIONPs) with protocatechuic acid (PCA) which served as a stabilizer and a linkage for a further functional layer. A new perfusion agent with magnetic imaging capability was produced by the adsorption of biocompatible passivating agent macro-aggregated albumin (MAA) on the PCA-coated MIONPs. PCA-coated MIONPs were investigated using infrared spectroscopy, thermogravimetric analysis and dynamic light scattering while adsorption of MAA was analysed by transmission electron microscopy, Fourier-transform infrared spectroscopy and x-ray diffraction methods. Magnetic measurements of samples indicated that all samples showed superparamagnetic behaviour. Cytotoxicity results revealed that the adsorption of MAA onto PCA-coated MIONPs provided an advantage by diminishing their toxicity against the L929 mouse fibroblast cell line compared to bare Fe3O4 © 2023 IOP Publishing Ltd.
AI in Nutrition: Multi-Criteria Analysis of Diet Plans Across Diverse Client Profiles
(Elsevier Inc., 2026) Erik, A.; Hamidy, S.M.; Karamancıoğlu, H.; Küçük Kırtıklı, B.N.
The advancement of artificial intelligence (AI) technologies has resulted in the proliferation of novel applications in various fields, including nutrition. One of the most notable applications involves AI-generated and guided diet plans. The present study evaluates diet plans generated by various AI tools (e.g., ChatGPT, Gemini, DeepSeek, etc.) for individuals with different health profiles using a multi-criteria decision-making (MCDM) framework. A series of authentic client scenarios were formulated on the basis of anonymized clinical cases that had been provided by a registered dietitian. These scenarios incorporated medical history, lifestyle habits, dietary patterns, and other relevant factors. For each client's profile, a set of standardized prompts were submitted to different AI tools to generate comparable diet plans. The resulting diet plans were evaluated based on several main and sub-criteria, including appropriateness, feasibility, nutritional adequacy, degree of personalization, ethical compliance, reproducibility, and linguistic clarity. The evaluation employed MCDM methods, namely LBWA for weighting, COPRAS, and PROMETHEE-I/II for ranking. The findings indicate that GPTPLUS demonstrated the highest overall ranking; DeepSeek exhibited consistent second-tier performance; and mid-tier models (GPT-4.0, GPT-4.5, Grook3) exchanged positions depending on the scenario and method. The results at the criterion level were found to be aligned with clinical priorities. Moreover, Claude's refusal to formulate a dietary plan for a client under the age of 18 indicates a paucity of standardized ethical guidelines governing the utilization of AI tools. The findings emphasize the potential of AI as a supportive tool in healthcare services, while concurrently addressing ethical considerations and practical limitations. © 2025 Elsevier Inc.

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