Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12294/1672

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Browsing Scopus İndeksli Yayınlar Koleksiyonu by Author "Abdullah H."

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    Article
    Antioxidant, Enzyme Inhibition, Toxicity, and Molecular Docking Analysis of Melaleuca Cajuputi Leaf Extract and Fractions
    (Visagaa Publishing House, 2023-12-15) Isah M.; Zengin G.; Wahab W.-N.-A.W.A.; Abdullah H.; Sul’ain M.D.; Uba A.I.; Jamil S.
    Melaleuca cajuputi plant has piqued the interest of researchers due to its pharmacological properties. However, there is scarce information regarding its enzyme inhibitory effects and possible mechanism of action. Thus, this study aimed to investigate the antioxidant, enzyme inhibitory, and potential binding interactions of bioactive components in M. cajuputi extract and fractions with the target enzymes. The 1,1-diphenyl-2-picrylhydrazyl radical scavenging (DPPH) assay was used for the antioxidant activity. The enzyme inhibition potential was assessed using tyrosinase and acetylcholinesterase (AChE) enzymes. M. cajuputi methanolic extract (MCME) demonstrated the most potent scavenging activity in comparison to Melaleuca fraction (MF1) and (MF2), as evidenced by IC50 values of 28.14 ± 0.96, 35.26 ± 0.64, and 80.90 ± 0.17 µg/mL, respectively. Similarly, the results of the enzyme inhibition assay showed that the MCME (IC50 65.81± 0.39 µg/mL) had the highest potency on tyrosinase enzyme compared to MF1 (IC50 131.3± 0.43 µg/mL) and MF2 (IC50 215.3 ± 0.48 µg/mL). However, MF2 (IC50 3.35 ± 0.37 µg/mL) showed a remarkable AChE enzyme inhibition than MCME and MF1. On the other hand, MCME possessed a low toxicity effect with an LC50 of 781 ± 0.07 µg/mL, whereas MF1 and MF2 were non-toxic. The 10-methylanthracene-9-carboxaldehyde, 2-isopropyl-10-methylphenanthrene, 2-tert butylanthracene, β-eudesmol, and α-eudesmol showed a strong binding propensity ranging from-5.1 to-6.2 and-6.4 to-7.6 kcal/mol towards tyrosinase and AChE respectively. The leaf extract of M. cajuputi could be considered a novel source of naturally occurring antioxidants and promising enzyme inhibitors. © 2024 Visagaa Publishing House.
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    Erratum
    Erratum to " Antioxidant, Enzyme Inhibition, Toxicity, and Molecular Docking Analysis of Melaleuca Cajuputi Leaf Extract and Fractions" (Natural Resources for Human Health, 2024, 4(1): 89-97)
    (Visagaa Publishing House, 2024-06-19) Isah M.; Zengin G.; Wan Abdul Wahab W.-N.-A.; Abdullah H.; Sul’ain M.D.; Uba A.I.; Jamil S.
    The authors would like to draw your attention to an error in the Results section, subsection Antioxidant Activity of the above article. The correction is as follows • (ascorbic acid) had an IC50 value of 7.40 g/mL [Page 92]-Incorrect text • (ascorbic acid) had an IC50 value of 7.40µg/mL [Page 92]- correct text. © 2024, Visagaa Publishing House. All rights reserved.